Using MK-677 is very simple and easy, because it is an oral supplement and complicated protocols are not involved. It can be used for an extended period of time, up to 10 weeks. A moderate daily dose is 25 mg. Some experienced lifters use 50 mg and higher doses. However, this is not necessary if you are using the supplement for the first time. It is also possible to adjust the dose during the cycle. If you feel that the dose you are taking is not strong enough to produce the expected results, you can increase it a little and see if it has a stronger effect. And vice versa, maybe you can get the same results by taking a lower dosage. All are different, but the standard dose of 25 mg a day does a good job with most users.
If you look at the bodybuilding circles, you will see that many people have been successful in combining Bosspeptides MK-677, Candarine and Andarine. Used together, these products form a large cutting stack. A powerful cutting cycle of these three supplements would last 10 weeks. You should take 25 mg of MK-677, 20 mg of Cardarine and 25 mg of Andarine daily. This is a cycle for more advanced users, but it is sufficient to produce a level worthy of conditioning, vascularization and thinness.
Benefits of MK-677
1) Improves sleep
One study showed that in both younger and older subjects, MK-677 improved sleep quality and REM (rapid eye movement) sleep duration.
In addition to scientific studies, there have been many reports of subjective improvements in sleep quality, through various online forums.
2) Fights aging and can increase longevity
The secretion of growth hormone (GH) and muscle mass both decrease by mid-puberty throughout life.
In a study of the elderly, daily ibutamorphine increased GH and IGF-1 levels to those of healthy young adults without serious adverse effects. IGF-1 is known to have beneficial effects on longevity.
In another study, MK-677 has rejuvenated the growth hormone profile in obese subjects.
3) Maggio Having nootropic effects
Some people use MK-677 as a nootropic because it acts on the ghrelin receptor, which has nootropic effects. You can read more about these effects in the ghrelin post. However, science has yet to study whether and how MK-677 influences cognitive performance.
4) It is useful in the treatment of growth hormone deficiency
Boss peptides MK-677 may increase levels of growth hormone, IGF-1 and IGFBP-3 in children with growth hormone deficiency. Furthermore, these effects are obtained without changing the concentrations of prolactin, glucose, triiodothyronine (T3), thyroxine (T4), thyrotropin, cortisol or insulin.
In men with severe GH, MK-677 increased IGF-1 and growth hormone without significant changes in cortisol, PRL and thyroid hormone levels. However, insulin and glucose have been increased.
5) It can help with wound healing and tissue regeneration
Growth hormone increases tissue regeneration and wound healing, so MK-677 can help with these.
There are individual accounts of MK-677 that are useful, but scientific studies are lacking.
Secondary effects in MK-677
The most frequent side effects of MK-677 are an increase in appetite and mild edema of the lower limbs and muscle pain (R).
Several studies report an increase in fasting blood glucose and a decrease in insulin sensitivity (R, R).
These side effects are similar to those seen in people with high levels of growth hormone, mainly joint pain and insulin resistance (R, R).
Although most studies report few or no side effects, one study was discontinued due to serious adverse events. In elderly patients with hip fractures, MK-677 has increased blood pressure, blood glucose and HbA1c, and there have been cases of congestive heart failure (R). Patients with congestive heart failure were over 80 and had a history of previous heart failure.
It would be prudent to observe carbohydrate intake and regularly monitor blood sugar and insulin levels while taking MK-677.
As an anabolic, MK-677 should be avoided if you have cancer. Both growth hormone and IGF-1 can promote cancer growth.